This question is a risk check. They want to know you have thought about the downsides.
What not to lead with
Commute, childcare, flexibility, travel. All legitimate, none reassuring. They describe what remote work does for you, not what you do with it.
What to lead with
How you work best, with evidence. "I do my best work in long uninterrupted blocks, and I have run two projects fully remote where I reported progress weekly in writing." That answers the actual worry.
Acknowledge one downside
Saying "the hardest part is that problems surface later, so I over-communicate early" shows you have done it before. Candidates who describe remote work as pure upside sound like they have not.
Common questions
Is it bad to say I want remote work for flexibility?
Mention it second, not first. Lead with output, then flexibility as a supporting reason.
What if I have never worked remotely?
Say so, and describe the closest equivalent — a period of autonomous work or a distributed project.